China, Australia and USA: Host-derived extracellular exosomes act as a defence mechanism during Haemonchus contortus parasitic infections.

Transcriptome analysis unraveled potential mechanisms of resistance to Haemonchus contortus infection in Merino sheep populations bred for parasite resistance

Runfeng Zhang, Fang Liu, Peter Hunt, Congjun Li, Lichun Zhang, Aaron Ingham and Robert W. Li | College of Life Science, Hubei Normal University, Huangshi, Hubei, China; College of Food Science and Engineering, Ocean University of China, Qingdao, China; CSIRO Agriculture and Food, Armidale, NSW, Australia; United States Department of Agriculture, Agriculture Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD, USA; Branch of Husbandry, Jilin Academy of Agricultural Science, Gongzhuling, Jilin, China; CSIRO Agriculture and Food, St Lucia, Queensland, Australia. | 2019 | Vet Res; 50:7

Gastrointestinal nematode, Haemonchus contortus, is a major health concern for livestock production systems where it can cause large production losses. In this study, RNA-sequencing technology was used to identify transcriptomic responses in resistant and susceptible line sheep flocks in order to understand the molecular mechanisms of resistance to H. contortus infections. Analysis of transcriptomic responses reveal 38 genes are differentially expressed between resistant and susceptible lines. 12 of these genes and their expression where further by qRT-PCR that was performed on the MIC Real-Time PCR Cycler.