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June 4, 2024 | Myra Scripts, NGS


The Chromium Single Cell Multiome ATAC + Gene Expression platform from 10X Genomics enables simultaneous profiling of chromatin accessibility and gene expression in the same single cells, providing comprehensive insights into cellular states and regulatory mechanisms. Automating this kit offers significant benefits, including increased throughput, enhanced reproducibility, and improved time efficiency. In particular, automating the clean-up steps is crucial to producing quality libraries. Clean-up of libraries is the most cumbersome task and is prone to human error, which can lead to reduced quality and reproducibility. By automating these steps, it reduces human error by providing consistency and standardisation, ensuring more reliable, reproducible and high-quality results. Furthermore, it optimizes the use of reagents and consumables, reducing waste and lowering costs. These benefits collectively improve the accuracy, reliability, and cost-effectiveness of the workflow.

This protocol automates Chromium Next GEM Single Cell Multiome ATAC + Gene Expression – Step 3 Post GEM Incubation Cleanup steps for up to 8 libraries on the Myra where the 96 Well Magnetic Station is used for the clean-up steps. By automating the pipetting-intensive steps, human error can be eliminated, thereby providing high-quality reproducible results, and increasing overall productivity.

More information on the protocol can be found via Download the Protocol PDF.

Revision History

3 June 2024Initial version