Skip to main content
Hit enter to search or ESC to close
Close Search
Bio Molecular Systems
  • Products
    • Mic qPCR Cycler
    • Myra Liquid Handler
    • Mic IVD
  • About us
  • News
  • Login
  • Contact Us
  • Request a Demo

South Korea: A novel chlorhexidine-releasing polydimethylsiloxane coating for polymethyl methacrylate dental restorations was developed

  • February 15, 2021

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Hang-Nga Mai, Do-Yeon Kim, Dong Choon Hyun, Ju Hayng Park, Sang Min Lee and Du-Hyeong Lee|Department of Prosthodontics, School of Dentistry, Institute for Translational Research in Dentisty, Kyungpook National University, Daegu 41940, Korea; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea; Department of Polymer Science and Engineering, Kyungpook National University, Daegu 41940, Korea|Journal of Clinical Medicine|2019|8, 1831; doi:10.3390/jcm8111831

Polymethyl methacrylate (PMMA) is a biocompatible and nondegradable acrylic resin that is frequently used in restorative material in the dental industry. PMMA restorations tend to have more surface defects, higher porosity and water absorptiveness compared to metal or ceramic restorations. This can lead to the development of micropores which can act as potential incubation chambers for bacteria, resulting in inflammation in the gingival tissue. In this study, a novel chlorhexidine (CHX)-releasing polydimethylsiloxane (PDMS) coating for PMMA restorations was developed. Mesoporous silica nanoparticles (MSNs) were used to encapsulate the CHX before being delivered to PDMS. MSNs provide superior physiochemical properties, excellent biocompatibility, cost effectiveness and high loading capacity for various biomolecules due to their high porosity. The loading and release capacity of CHX was measured using liquid chromatography and the biological safety was evaluated using cytotoxicity tests. Relative quantification was performed on the Mic qPCR Cycler to analyse the intracellular molecular events. The specimens did not alter the phosphor-ERK signalling activation or phosphor-Histone 3 (ser10) levels, confirming that the specimens did not affect the cellular mitotic activity in general. To conclude, the CHX-loaded PDMS-based antibacterial coating for PMMA restorations shows a slow and stable release of CHX. The cell viability assay showed the non-toxicity of the synthesized coating substance.

Read More

  • Previous Project
  • Next Project

Ready to produce quality data faster?

DOWNLOAD THE SOFTWARE
REQUEST A DEMO
  • Mic
  • Myra
  • About us
  • News
  • Login/Register
Bio Molecular Systems

© 2023 Bio Molecular Systems – all rights reserved

  • BMS Privacy Policy
  • Mic qPCR Warranty
  • Myra Warranty
  • Contact
  • sales@biomolecularsystems.com

  • twitter
  • facebook
  • linkedin
  • youtube
Close Menu
  • Products
    • Mic qPCR Cycler
    • Myra Liquid Handler
    • Mic IVD
  • About us
  • News
  • Login
  • Contact Us
  • Request a Demo
Cookie NoticeThis website uses cookies to improve your user experience. Details on what cookies we use can be found in our privacy policy.
Accept
Read more
Manage Cookies
Cookie Box Settings
Cookie Box Settings
 

Privacy settings

Decide which cookies you want to allow.You can change these settings at any time. However, this can result in some functions no longer being available. For information on deleting the cookies, please consult your browser’s help function.Learn more about the cookies we use.

With the slider, you can enable or disable different types of cookies:

  • Block all
  • Essential
  • Functionality
  • Analytics
  • Advertising

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected

This website won't:

  • Remember your login details
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track on the time spent on each page
  • Analytics: Increase the data quality of the statistics functions
  • Advertising: Tailor information and advertising to your interests based on e.g. the content you have visited before.
  • Advertising: Gather personally identifiable information such as name and location

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country

This website won't:

  • Remember your login details
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track on the time spent on each page
  • Analytics: Increase the data quality of the statistics functions
  • Advertising: Tailor information and advertising to your interests based on e.g. the content you have visited before.
  • Advertising: Gather personally identifiable information such as name and location

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected
  • Functionality: Remember social media settingsl Functionality: Remember selected region and country
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track on the time spent on each page
  • Analytics: Increase the data quality of the statistics functions

This website won't:

  • Remember your login details
  • Advertising: Use information for tailored advertising with third parties
  • Advertising: Allow you to connect to social sites
  • Advertising: Identify device you are using
  • Advertising: Gather personally identifiable information such as name and location

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected
  • Functionality: Remember social media settingsl Functionality: Remember selected region and country
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track on the time spent on each page
  • Analytics: Increase the data quality of the statistics functions
  • Advertising: Use information for tailored advertising with third parties
  • Advertising: Allow you to connect to social sites
  • Advertising: Identify device you are using
  • Advertising: Gather personally identifiable information such as name and location

This website won't:

  • Remember your login details
Save & Close