Iraq: micro-RNA levels in follicular fluid indicate embryo quality

Comparison between effect of long agonist and antagonist protocols on micro-RNA- 320 level in follicular fluid during IVF – ICSI.

Mufeda Ali Jwad, Ban Abbas and Ula Al-Kwaz | M.B.ch.B/ MSc. Applied Embryology. High Institute for Infertility Diagnosis & Assisted Reproductive Technology / Al – Nahrain University; M.B.ch. B/M.S.c, Ph.D Molecular Pathology, Medical collage/ Al- Nahrain University; High Institute for Infertility Diagnosis & Assisted Reproductive Technology. | 2018 | International Journal of Advanced Research (IJAR) | 6(12), 01-07

Infertility is a big problem in our world today as child-bearing is increasingly delayed. The study investigated the correlation between miRNA-320 levels in follicular fluid and the age and BMI of the patient, number of dominant follicles, number of oocytes retrieved, abnormal oocytes and number of fertilized oocytes. Micro-RNA (miRNA) -320 in the follicular fluid was also quantified using Magnetic Induction Cycler (MIC) and compared the two treatment groups (antagonistic and agonistic treatment protocols) as well as the differing grades of embryo quality within the groups. The study proves that miRNA-320 is a good indicator of embryo quality and that using qPCR assay is a reliable and non-invasive way to detect embryo quality.