Protective effect of enzymatic hydrolysates from seahorse (Hippocampus abdominalis) against H2O2-mediated human umbilical vein endothelial cell injury
Yunok Oh, Chang-Bum Ahn, Na Young Yoon, Ki Ho Nam, Yeon-Kye Kim, Jae-Young Je | Department of Marine-Bio Convergence Science, Pukyong National University, Busan 48547, Republic of Korea; Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea; Food & Safety Division, National Fisheries Research & Development Institute, Busan 46083, Republic of Korea | 2018 | Biomedicine & Pharmacotherapy | 108, 103-110
Elevated LDL oxidation by excessive reactive oxygen species (ROS) plays a key pathogenesis role in the early inflammatory of atherosclerotic lesions. The study determined the most promising hydrolysate for an anti-atherosclerotic agent using the seahorse species, H. abdominalis. Seahorse H. abdominalia alcalase hydrolysate (SHAH) was selected and evaluated for inhibition ability against LDL oxidation. The effect of SHAH on the expression of apoptosis-related genes was analysed using qPCR. The qPCR assay using the MIC revealed that SHAH reduced cell death and provides insight into new treatments using seahorse.
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